Peripheral human T cells sensitized in mixed leukocyte culture synthesize and express Ia-like antigens.

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Peripheral human T cells sensitized in mixed leukocyte culture synthesize and express Ia-like antigens

We have studied the modulation of Ia-like antigens on the surface membrane of human T cells responding in a one-way mixed leukocyte culture. A heterologous antiserum, (anti-p23,30), which is specific to HLA-D-related antigens and which is unreactive with normal peripheral T cells or thymocytes, was found to bind significantly to all T cells transformed in mixed leukocyte culture (MLC) as determ...

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Human alveolar macrophages express Ia-like antigens.

Monoclonal antibody to la-like antigens was used to demonstrate the presence of these antigens on human alveolar macrophages. Immunoprecipitation demonstrated the 27,000 and 34,000 molecular weight peaks that correspond to the la-like antigen subunits. Immunofluorescence confirmed the presence of la-like antigens on alveolar macrophages but not on other bronchoalveolar cells. The presence of al...

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Comparison of Functional Competence of Umbilical Cord and Adult Peripheral Blood Dendritic Cells in Allogenic Mixed Leukocyte Reaction

Background: Dendritic cells (DCs) are the most potent stimulators of primary T cell responses and play a key role in immune reactions after stem cell transplantation. Very little is known about the cord blood (CB) dendritic cells and their potential involvement in the low incidence and lower severity of acute graft-versus-host disease after CB transplantation.   Objectives: The aim of this stud...

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Human erythroid progenitor cells express Rhesus antigens.

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T lymphocytes expressing human Ia-like antigens in infectious mononucleosis (IM).

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ژورنال

عنوان ژورنال: Journal of Experimental Medicine

سال: 1978

ISSN: 0022-1007,1540-9538

DOI: 10.1084/jem.148.5.1440